Sam-e 400

What does SAM-e 400 do?

Jarrow FORMULAS® pharmaceutical grade, stabilized SAM-e 400 provides a full 400 mg elemental SAM-e from 800 mg of SAM-e tosylate disulfate. SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.

Contains More of the Active S,S Form

SAM-e (S-Adenosylmethionine) is a chiral molecule and therefore consistsof two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the(S,S) structure, while the (R,S) structure is biologically inactive.

Jarrow FORMULAS® SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available. SAM-e is an amino acid derivative that has been clinically proven to benefit brain, joint and liver function.* Found in all living cells, SAM-e is often referred to as “activated” methionine (an essential amino acid) since it is formed by the combining of ATP with methionine. SAM-e has undergone dozens of trials involving thousands of patients. Researchers studying the beneficial effects of SAM-e have identified the following benefits of SAM-e:

Joint Strength

SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.

Brain Metabolism

SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-dopa, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).

Longevity

Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process. Proper methylation through substances such as SAM-e positively influences longevity.

Liver

SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathionedependent enzymes (glutathione peroxidase and glutathione-S-transferase), hich are substances important for liver function.

Suggested Usage:

Take 1 tablet per day on an empty stomach, or as directed by your qualified health care consultant.

WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re- Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e.

Jarrow FORMULAS® SAM-e 400foil blister-packed to maximize stability and safety. Do not use if outer seal of blister pack is broken.

Other Ingredients:

Microcrystalline cellulose, silicon dioxide, glycerol behenate, magnesium stearate (vegetable source), enteric coating (methacrylate copolymers), titanium dioxide, talc, triethylcitrate, riboflavin, glycerol palmitostearate, medium chain triglycerides, and carboxymethylstarch sodium salt.

Suitable for vegetarians/vegans.

No wheat, no gluten, no soy, no dairy, no egg, no fish/shellfish, no nuts/tree nuts.

This product complies with the proposed USP Monograph for SAM-e.